BIOCHEMICAL SIGNS OF THE COURSE OF REPARATIVE OSTEOGENESIS IN PATIENTS WITH FRACTURES OF THE LOWER EXTREMITY

Background: Some biochemical indicators in patients with disorders of reparative osteogenesis were described a sufficient number studies, but the role factors affecting metabolism bone tissue and ways their correction are not sufficiently studied .. For effective prediction course fractures, it is important to identify early markers impaired consolidation and, accordingly, its pathogenetic correction. Purpose: determine multiple monolocal fractures bones lower limb. Materials Methods: 44 aged 23 47 years examined. To assess ratio intensity processes biosynthesis breakdown collagen, as major structural protein connective tissue, following determined blood serum patients: fractions hydroxyproline, oxyproline, collagenase, cathepsin B, elastase, proteolysis-antielastase inhibitors. In addition, mineral also content calcium, phosphorus, alkaline phosphatase activity. Results: A comparative analysis comparison results examination closed tibial revealed that already at beginning research, deviations from norm both collagen observed. Both groups characterized by presence disturbances between calcium - an increase level phosphatase. The detected changes had more pronounced intense character due injuries large destroyed cells first days after injury. Conclusions: Indicators unfavorable decrease calcium/phosphorus serum, free oxyproline collagenolytic enzymes (collagenase, B). Besides, there proteolysis inhibitors (antielastase, 2-macroglobulin) suspension stability antioxidant activity, fibrinolytic Our findings justify need for prophylactic drugs improve soon injury (within month) order activate regeneration.